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Sarecycline hydrochloride

Name: Sarecycline hydrochloride
Brand: TargetMol
SKU: T21394
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21394Cas No. 1035979-44-2

Alias WC-3035, WC3035, WC 3035, Sarecycline HCl, P-005672, P005672, P 005672

Sarecycline hydrochloride (Sarecycline HCl) is an orally active narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity, inhibits Acinetobacter and Candida tropicalis, and can be used to treat inflammatory acne.

Sarecycline hydrochloride

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Purity: 99.23%

Catalog No. T21394Alias WC-3035, WC3035, WC 3035, Sarecycline HCl, P-005672, P005672, P 005672Cas No. 1035979-44-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$257	In Stock	In Stock
10 mg	$373	In Stock	In Stock
25 mg	$581	In Stock	In Stock
50 mg	$768	In Stock	In Stock
100 mg	$1,050	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.23%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Sarecycline hydrochloride (Sarecycline HCl) is an orally active narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity, inhibits Acinetobacter and Candida tropicalis, and can be used to treat inflammatory acne.
In vitro	METHODS: To evaluate the antibacterial activity of Sarecycline hydrochloride and its comparator against Cutibacterium acnes, Sarecycline hydrochloride was applied to 55 clinical isolates of Cutibacterium acnes. RESULTS: The MIC values of Sarecycline hydrochloride ranged from 0.5 to 16 μg/ml and it displayed activity against macrolide-resistant strains [1].
In vivo	METHODS: To determine the in vivo efficacy of Sarecycline hydrochloride against Staphylococcus aureus RN450-1 and Escherichia coli PBS1478, a murine model of systemic (intraperitoneal) infection was utilized. RESULTS: Sarecycline hydrochloride effectively treated systemic infections caused by Staphylococcus aureus, with a protective dose at 50% (PD50) value of 0.25 mg/kg[1].
Synonyms	WC-3035, WC3035, WC 3035, Sarecycline HCl, P-005672, P005672, P 005672

Chemical Properties

Molecular Weight	523.96
Formula	C₂₄H₃₀ClN₃O₈
Cas No.	1035979-44-2
Smiles	O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(CN(OC)C)C=CC4O)[H])[H].Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 5.26 mg/mL (10.04 mM), Sonication is recommended.

DMSO: 80 mg/mL (152.68 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9085 mL	9.5427 mL	19.0854 mL	95.4271 mL
5 mM	0.3817 mL	1.9085 mL	3.8171 mL	19.0854 mL
10 mM	0.1909 mL	0.9543 mL	1.9085 mL	9.5427 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0954 mL	0.4771 mL	0.9543 mL	4.7714 mL
50 mM	0.0382 mL	0.1909 mL	0.3817 mL	1.9085 mL
100 mM	0.0191 mL	0.0954 mL	0.1909 mL	0.9543 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc